Jeudi, 5 février⋅– 11:00
Séminaire de F. Caudron / amphi Riquet
Whi3 Condensation and RNARegulation: A Molecular Switch for Yeast Deceptive Courtship Memory
Prions and prion-like proteins are master regulators of cellular memory andstress adaptation, driving critical decisions such as cell cycle entry.In Saccharomyces cerevisiae, the prion-like protein Whi3 acts as amolecular switch: its condensation encodes the memory of deceptive courtship,enabling cells to bypass G1-phase arrest and restart division. But how doesWhi3 sense and integrate signals? What triggers its condensation, and is Whi3alone in this role?
In this seminar, I will present our efforts to reconstitute Whi3condensation in vitro, and discuss how Whi3’s conformationalchange triggers a functional switch—shifting from repressing CLN3 mRNAtranslation in its soluble state to enabling cell cycle progression uponcondensation. I will show how Whi3 integrates the biophysicalstate of the plasma membrane to form condensates and will explore how Whi3and other prion-like proteins assemble into a regulatory network,orchestrating the pivotal decision of cell cycle entry.
Jeudi, 12 février⋅– 09:00 à 12:00 Amphi Riquet
Assemblée générale
Vendredi, 13 février
PhD Day
Mardi, 17 février⋅– 14:00 à 17:00 – 400-
Atelier de réflexion collective transition écologique 🌱
Mercredi, 18 février⋅-10:00 à 11:00
☕Newcomers Coffee break
