Vendredi, 19 janvier⋅09:30 à 11:10
Quatrième Meeting du pole PRISM
Vendredi, 26 janvier⋅14:00
PhD defense – Ellen Donker
“The three disordered domains of the Knr4 protein and their role in stress hypersensitivity and protein-protein interactions in the yeast Saccharomyces cerevisiae“.
Mardi, 6 février⋅09:00 à 17:15
Journée des doctorants
Jeudi, 8 février⋅10:00 à 12:00
Amphi Riquet
Assemblée générale
Jeudi, 29 février⋅13:00
Séminaire Karel Anton Miettinen
Assistant Professor, Department of Plant and Environmental Sciences University of Copenhagen
Title: Towards computer guided precision fermentation
abstract Microbial bio-production of small molecules is a scalable and sustainable alternative to petrochemical production of pharmaceuticals, industrial chemicals and agronomic agents. However, developing novel bio-production processes usually requires discovery of suitable biocatalysts and establishing their heterologous expression in purpose engineered host microbes. During my stay a University of Leiden, PSB-UGent and university of Copenhagen, I have contributed to establishing biotechnological production of complex molecules including anti-cancer alkaloids, the anti-obesity agent celastrol and other bio-active triterpenoids through this approach. Nevertheless, reaching commercially viable bio-production of complex molecules requires establishing a new generation of biotechnological processes, going beyond the typical crude overexpression of enzymes. In order to optimize compound production, we need to dynamically control key aspects of fermentation, from tuning heterologous gene expression and native precursor metabolism, to optimizing fermentor conditions. Such a complex task cannot be performed manually. Therefore, I propose establishing two-way optogenetic communication between cell and computer steer bio-factories at the genetic level. This would enable full utilization of modern informatics such as machine learning to control fermentation, permitting automated experimentation and process optimization.
